Quinidine and Unidirectional Cation Fluxes in Atria

1 January 1960

journal article
research article
Published by Wolters Kluwer Health in Circulation Research

Vol. 8 (1) , 246-252
https://doi.org/10.1161/01.res.8.1.246

Abstract

The effect of quinidine on unidirectional fluxes of Na and K in isolated rabbit atria has been investigated and correlated with known effects of the drug on the electrical and mechanical properties of the heart. Quinidine caused a rapid inhibition of Na entry, which secondarily depressed K efflux. In addition, the drug depressed membrane permeability to K and caused a marked inhibition of active transport, both of which were relatively slow in onset.

Keywords

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