CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation
- 5 February 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 283 (5403) , 848-851
- https://doi.org/10.1126/science.283.5403.848
Abstract
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3′,5′-monophosphate (cAMP)–specific phosphodiesterase-7 (PDE7) was found to be a consequence of such costimulation. Increased PDE7 in T cells correlated with decreased cAMP, increased interleukin-2 expression, and increased proliferation. Selectively reducing PDE7 expression with a PDE7 antisense oligonucleotide inhibited T cell proliferation; inhibition was reversed by blocking the cAMP signaling pathways that operate through cAMP-dependent protein kinase (PKA). Thus, PDE7 induction and consequent suppression of PKA activity is required for T cell activation, and inhibition of PDE7 could be an approach to treating T cell–dependent disorders.Keywords
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