Potentiating effects of caffeine of teratogenicity of alkylating agents in mice

1 August 1983

journal article
research article
Published by Wiley in Teratology

Vol. 28 (1) , 29-33
https://doi.org/10.1002/tera.1420280106

Abstract

Teratogenic to subteratogenic doses of x‐ray, mitomycin C, MNNG, thio‐TEPA, cyclophosphamide, and chlorambucil were administered to pregnant ICR mice together with caffeine at doses of 12.5, 25, or 50 mg/kg on day 11 of gestation. Fetuses were examined for gross malformations on day 18 of gestation. The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg. The teratogenicity of chlorambucil was also significantly potentiated by caffeine at 50 mg/kg, but similar potentiation was not observed for x‐ray, MNNG, thio‐TEPA, and cyclophosphamide.

Keywords

This publication has 14 references indexed in Scilit:

Teratogenic effect ofN-methyl-N′-nitro-N-nitrosoguanidine in mice
Teratology, 1978
Cell Death and Reduced Proliferative Rate
Published by Springer Nature ,1977
Caffeine
Mutation Research/Reviews in Genetic Toxicology, 1977
Effects of caffeine on the genetic material
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside
Teratology, 1971
TERATOGENICITY OF CAFFEINE IN MICE RELATED TO ITS MODE OF ADMINISTRATION
The Japanese Journal of Pharmacology, 1969
Teratogenic Actions of Some Methylated Xanthines in Mice
Okajimas Folia Anatomica Japonica, 1969
Effects of Mitomycin C Administered at Various Stages of Pregnancy upon Mouse Fetuses
Okajimas Folia Anatomica Japonica, 1968
Relationship of dosage and time of administration to teratogenic effects of thio-TEPA in mice
Okajimas Folia Anatomica Japonica, 1968
Congenital Malformations in Offspring of Mice Treated with Caffcine.
Experimental Biology and Medicine, 1960