R-spondin1 and FOXL2act into two distinct cellular types during goat ovarian differentiation
Open Access
- 2 April 2008
- journal article
- Published by Springer Nature in BMC Developmental Biology
- Vol. 8 (1) , 36
- https://doi.org/10.1186/1471-213x-8-36
Abstract
Up to now, two loci have been involved in XX sex-reversal in mammals following loss-of-function mutations, PIS (Polled Intersex Syndrome) in goats and R-spondin1 (RSPO1) in humans. Here, we analyze the possible interaction between these two factors during goat gonad development. Furthermore, since functional redundancy between different R-spondins may influence gonad development, we also studied the expression patterns of RSPO2, 3 and 4.Keywords
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