Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (4) , 1071-1073
- https://doi.org/10.1248/cpb.37.1071
Abstract
The induction of edema in the mouse ear has been established as a reliable in vivo assay for tumor promoters. Therefore, inhibitors of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema are most likely to be inhibitors of skin tumor promotion. Besides the application for this assay for the screening of compounds, it also allows comparison of the activities of groups of related compounds such as flavonoids. Results obtained in this way showed that the double bond at C-2 and C-3 of the flavonoid structure is a prerequisite for anti-tumor-promoting activity, and indicated that activity in this screening assay for inhibitors of TPA-induced ear edema reflects the anti-tumor-promoting effect in two-stage carcinogenesis.This publication has 5 references indexed in Scilit:
- Inhibitory Effect of Glycyrrhizin and Caffeine on Two-stage Carcinogenesis in MiceYAKUGAKU ZASSHI, 1988
- Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetateCancer Letters, 1986
- The mouse ear edema: A quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotionCancer Letters, 1984
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibitionCarcinogenesis: Integrative Cancer Research, 1983
- Tachyphylaxis in 12-0-Tetradecanoylphorbol Acetate- and Arachidonic Acid-Induced Ear EdemaJournal of Investigative Dermatology, 1983