Inhibitory Effect of Human Urinary Trypsin Inhibitor (Urinastatin) on Lysosomal Thiol Proteinases
Open Access
- 31 December 1985
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 42 (4) , 571-574
- https://doi.org/10.1254/jjp.42.571
Abstract
Effects of human urinary trypsin inhibitor, urinastatin, a compound clinically prescribed for treatment of acute pancreatitis, on lysosomal thiol proteinases were studied. Urinastatin had inhibitory effect on the activities of cathepsins B and H in vitro. In the experimental acute pancreatitis induced by a closed duodenal loop, urinastatin prevented the enhancement of esterolytic activity and the activities of cathepsins B and H. Urinastatin also improved the activities of inhibitors of cathepsins B and H in the case of pancreatitis.This publication has 12 references indexed in Scilit:
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