Ex VivoProgramming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation
- 1 January 2006
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 25 (3-4) , 83-97
- https://doi.org/10.1080/08830180600743131
Abstract
Plasmids used in DNA vaccination not only serve as a source of antigen, but also have an important adjuvant effect. This review focuses on recent advancements made in understanding how cells internalize DNA, and how internalized DNA activates immune response pathways. We also comment on the role of B cells in both of these processes.Keywords
This publication has 59 references indexed in Scilit:
- Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune ResponseImmunity, 2006
- A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNANature Immunology, 2005
- CpG oligodeoxynucleotides induce IL-8 expression in CD34+ cells via mitogen-activated protein kinase-dependent and NF-κB-independent pathwaysInternational Immunology, 2005
- Spontaneous uptake of biologically active recombinant DNA by mammalian cells via a selected DNA segmentGene Therapy, 2004
- Activation of RAW264.7 Macrophages by Bacterial DNA and Lipopolysaccharide Increases Cell Surface DNA Binding and InternalizationPublished by Elsevier ,2004
- Regulation of Receptor‐Dependent Activation of the Innate Immune ResponseThe Journal of Infectious Diseases, 2003
- Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartmentsEuropean Journal of Immunology, 2002
- Cytokine gene expression in epidermis with biological effects following injection of naked DNANature Genetics, 1995
- CpG motifs in bacterial DNA trigger direct B-cell activationNature, 1995
- Antigen-specific interaction between T and B cellsNature, 1985