Failure of Zymosan to Increase Survival in X-Irradiated Mice.

Open Access
Publisher Website
Google Scholar
Abstract
Premedication with 5 mg/kg of zymosan intravenously or intraperitoneally did not significantly increase surivival in irradiated mice. With intravenous injections of 125 mg/kg on pre-irradiation days 14 and 3, a significant reduction in the mean survival time (ST50) day was seen. Similar results were obtained with both doses when injections were given after irradiation. The beneficial effects of zymosan in the treatment of radiation injury in mice reported by Ross and Pillemer could not be confirmed.