CHARACTERIZATION OF HYALURONECTIN IN HUMAN-TUMOR HETEROGRAFTS IN THE NUDE-MOUSE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 3  (4) , 325-334
Abstract
Three established cell lines [CB91, CB 76 and CB 109] derived from 3 human astrocytomas were grafted into nude mice. Hyaluronectin, a marker of loose connective tissue, was detected in the grafts. The histopathology and the hyaluronectin staining were similar to those of the tumors of origin. Absorption experiments demonstrate that one of the 3 human grafted tumors (CB 109) contains a human type hyaluronectin, in contrast to the other 2. In these 2 grafts, hyaluronectin is a constituent of the host stromal reaction, whereas in the CB 109 graft hyaluronectin apparently originates from the human tumor cells. This tumor could be used to test the production of human hyaluronectin in vitro and in vivo.

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