Bacterial bone resorption in noma (gangrenous stomatitis)

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Abstract
Bone resorption (gangrenous stomatitis) was found to be associated with extensive bacterial colonization of mandibular bone in 3 separate cases [human] of noma. Light microscopy and EM revealed a heterogeneous bacterial population with a long, filamentous, gram-positive organism predominantly in direct contact with the resorbing bone front. The bone was completely denuded and no osteoclastic activity was observed. The highly regular arrangement of the filamentous organism along the resorbing bone and the absence of osteoclastic activity suggested that bone resorption in noma is mediated by bacterial action.