A New Algorithm for Protein Design

Preprint

28 August 1995

preprint
Published by arXiv in arXiv

https://doi.org/10.48550/arXiv.cond-mat/9508127

Abstract

We apply a new approach to the reverse protein folding problem. Our method uses a minimization function in the design process which is different from the energy function used for folding. For a lattice model, we show that this new approach produces sequences that are likely to fold into desired structures. Our method is a significant improvement over previous attempts which used the energy function for designing sequences.

Keywords

FUNCTION FOR DESIGNING
DESIGNING SEQUENCES
PREVIOUS ATTEMPTS
FOLDING PROBLEM
ENERGY FUNCTION
REVERSE PROTEIN
PROTEIN DESIGN
DESIGN PROCESS
LATTICE MODEL
ALGORITHM

All Related Versions

Version 1, 1995-08-28, ArXiv
Published version: Physical Review Letters, 76 (2), 323.