New Algorithm for Protein Design
- 8 January 1996
- journal article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 76 (2) , 323-326
- https://doi.org/10.1103/physrevlett.76.323
Abstract
We apply a new approach to the reverse protein folding problem. Our method uses a minimization function in the design process which is different from the energy function used for folding. For a lattice model, we show that this new approach produces sequences that are likely to fold into desired structures. Our method is a significant improvement over previous attempts which used the energy function for designing sequences.Comment: 10 pages latex 2.09 no figures. Use uufiles to decodKeywords
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