Treatment of Adult Autoimmune Thrombocytopenic Purpura with High-Dose Intravenous Plasmin-Cleaved Gammaglobulins

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Abstract
We present the results of the treatment of 15 adult patients with chronic autoimmune thrombocytopenic purpura with high dose i.v. gammaglobulins. In 11 patients, this treatment produced a remission, complete (platelet counts above 100 times 109/1) in 5, partial (platelet counts between 50 and 100 times 109/1) in 6. In all these patients, the response was transient lasting 2–4 weeks. In 4 patients, no response was observed. We used plasmin‐cleaved gammaglobulins which caused rare and mild side effects and gave results similar to those reported with intact human gammaglobulins. The indications of high dose i.v. gamma‐globulins in the management of adult patients with autoimmune thrombocytopenic purpura are discussed.