DOSE‐RESPONSE RELATIONSHIPS FOR ADRENOCORTICOTROPHIN‐INDUCED HYPERTENSION IN MAN
- 1 January 1987
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 14 (1) , 65-71
- https://doi.org/10.1111/j.1440-1681.1987.tb00958.x
Abstract
SUMMARY: 1. Adrenocorticotrophin (ACTH), given as long‐acting Synacthen depot (Ciba‐Geigy), at 1000 μg/day, in divided doses 12 hourly, is known to increase blood pressure in man.2. Fifty μg/day of short‐acting Synacthen given intravenously produced a rise in blood pressure and may be a threshold dose.3. Twelve hourly intramuscular injections of short‐acting Synacthen over the dose range 100–400 μg/day was not sufficient to raise blood pressure.Keywords
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