Purification and characterization of a growth inhibitory hepatic peptide
- 1 December 1987
- journal article
- research article
- Published by Springer Nature in Virchows Archiv B Cell Pathology Including Molecular Pathology
- Vol. 54 (1) , 152-154
- https://doi.org/10.1007/bf02899207
Abstract
A pentapeptide isolated from normal mouse liver seems to inhibit DNA synthesis (3H-thymidine incorporation into liver DNA and labelling indices) and the mitotic rate (G 2-M cell flux) in regenerating mouse liver. The inhibitor is somewhat similar to the growth inhibitory pentapeptides previously reported for granulocytes and epidermis. It is active at very low dose levels, showing a bell-shaped dose-response curve.This publication has 9 references indexed in Scilit:
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