Experimental Rat model for Corynebacterium renale-induced pyelonephritis

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Abstract
The laboratory rat served as a model for ascending pyelonephritis after implantation of a Zn disk coated with C. renale into the urinary bladder because it satisfied 3 different criteria for infection. The production of an alkaline urine and the presence of significant numbers of C. renale in the kidneys, and distinct pyelonephritic lesions as revealed by histological examination, were observed in all rats infected with C. renale. Control rats that harbored sterile disks in their urinary bladders exhibited none of these effects.