EXPERIMENTAL SHIGELLA INFECTIONS V

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Abstract
Formal, SamuelB., (Walter Reed Army Institute of Research, Washington, D. C.),Gustave Dammin, Helmuth Sprinz, Donald Kundel, Herman Schneider, Richard E. Horowitz, and Martin Forbes. Experimental shigella infections. V. Studies in germ-free guinea pigs. J. Bacteriol.82:284–287. 1961.—Germ-free guinea pigs succumb after oral infection withShigella flexneriserotype 2a; they survive a similar challenge with either a strain ofEscherichia colior a culture of lactobacillus. Animals monocontaminated withE. colisurvive, whereas those monocontaminated with lactobacilli succumb to subsequent challenge with dysentery bacilli. Prior subcutaneous inoculation of heat-killedS. flexneri2a does not render germ-free guinea pigs resistant to the fatal infection with viable dysentery bacilli.

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