Application of dual parameter analysis in flow cytometric DMA measurements of paraffin-embedded samples
- 1 April 1994
- journal article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 23 (4) , 190-192
- https://doi.org/10.1111/j.1600-0714.1994.tb01111.x
Abstract
In a comparison of flow cytometric DNA measurements on fresh and paraffin-embedded material from primary squamous cell carcinomas of the head and neck region, we discovered that previously undetected aneuploid clones could be detected by dual parameter analysis of cytokeratin and DNA applied to disintegrated cells from paraffin sections. Using this new approach the correlation coefficient between DNA-indices from fresh and paraffin-embedded material increased from 0.423 to 0.904.Keywords
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