Genetics of Ia-like alloantigens in chickens and linkage withB major histocompatibility complex

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Abstract
Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens (“Ia”) and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the “la” antigens are determined by a single codominant locus and that theEa-B and “Ia” loci are on the same chromosome. Failure to detect a single recombinant between theEa-B and “Ia” loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The “Ia” genes are thus included in theB major histocompatibility complex of the chicken.