Interspeciesin vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560
- 16 May 2006
- journal article
- research article
- Published by Wiley in Journal of Mass Spectrometry
- Vol. 41 (6) , 771-780
- https://doi.org/10.1002/jms.1033
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitorBioorganic & Medicinal Chemistry Letters, 2005
- Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometryRapid Communications in Mass Spectrometry, 2004
- USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTESDrug Metabolism and Disposition, 2004
- Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 InhibitorThe Journal of Pharmacology and Experimental Therapeutics, 2004
- Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent bindingBioorganic & Medicinal Chemistry Letters, 2002
- Tandem mass spectrum of a farnesyl transferase inhibitor? gas-phase rearrangements involving imidazoleJournal of Mass Spectrometry, 2001
- PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigsClinical and Experimental Allergy, 1998
- Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthmaCanadian Journal of Physiology and Pharmacology, 1998
- The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant ActionsPublished by Elsevier ,1998
- The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheepEuropean Journal of Pharmacology, 1992