Synthesis of renin substrate by rat liver

Publisher Website
Google Scholar
Abstract
This present study attempted to determine if the isolated rat liver is capable of synthesizing renin substrate from 14C-labeled amino acids added in the perfusate. The renin substrate is characterized via reaction with renin, forming a substance that is subsequently identified as proangiotensin. Extensive evaluation of the reaction product is carried out by using molecular-sieve chromatography, countercurrent distribution, reactivity with converting enzyme, radioimmunological technique and bioassay. Isolated rat liver perfused with artificial salt solution is capable of synthesizing a protein that reacts with renin to form a radioactive substance indistinguishable from proangiotensin.

This publication has 14 references indexed in Scilit: