The relation of glycosuria to glycaemia and the determination of the renal threshold for glucose

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Abstract
The renal threshold for glucose, x, is calculated by the expression x = (W1B2-W2B1) /(W1-W2), where W1 and W2 are the glucose concentrations in mgm. per 100 cc. of two consecutive urine samples, B1 and B2 the corresponding blood sugar figures. The threshold with rising blood sugars may be either higher or lower than with falling; the two are usually not far apart. The thresholds range from 20 to 304 mgm. glucose per 100 cc. of blood in various conditions. Concentration of urinary sugar is said to be independent of diuresis and proportional to the excess of blood sugar over renal threshold. The concentration of sugar in the reabsorbed fluid is determined by the sugar content of the blood in the peritubular capillaries.