Changes in Liver Lipid Composition with Overnight Fasting

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Abstract
Fasting rats overnight from 8 p.m. to 8:30 a.m. produced significant changes in liver weight and liver fatty acid composition in comparison with fed rats killed at 8 p.m. and 8:30 a.m. In the fasted rats, the relative proportion (wt%) of phospho-lipid arachidonate increased and the wt% of phospholipid linoleate decreased. In liver triglycende the fasted rats had significantly higher proportions of arachidonate and linoleate and significantly lower proportions of oleate, palmitate, and palmitoleate. The total amount (mg/liver) of phospholipid and triglycende did not change significantly, but there was a significant decrease of liver weight. Feeding and fasting procedures and time of sacrifice of animals should be carefully standardized in studies of liver lipid composition to minimize variations related to the eatmg patterns of the animals.