Sequential changes in liver and heart lipids after giving linoleate or linoleate plus pyridoxine to rats depleted of fat and pyridoxine

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Abstract
Analyses were made of liver and heart lipids of male weanling rats, depleted of pyridoxine and fat and given supplements of methyl linoleate with or without 30 [mu]g of pyridoxine daily for 1,2, 4 and 6 days. In the liver, linoleate plus pyridoxine produced a higher concentration of liver cholesterol esters, phospholipids and phospholipid arachidonate, and a lower concentration of phospholipid linoleate, than treatment with linoleate alone. Treatment with linoleate significantly increased phospholipids and phospholipid arachidonate in comparison with the initial values. In the heart, treatment with linoleate plus pyridoxine produced higher concentrations of phospholipids, phospholipid arachidonate and cholesterol. Linoleate alone caused a significant decrease in phospholipid arachidonate and increased phospholipid linoleate. Rats given linoleate plus 10 [mu]g of pyridoxine daily gained as much weight as those given linoleate plus 30 [mu]g of pyridoxine, but differed considerably in the composition of their liver and heart lipids.