15-Deacetylsergeolide, a Potent Antileukemic Quassinoid From Picrolemma pseudocoffea
- 1 November 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 47 (6) , 994-996
- https://doi.org/10.1021/np50036a014
Abstract
Investigation of the leaf extract of P. pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and 2 known quassinoids, isobruceine B and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2.This publication has 4 references indexed in Scilit:
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- Antimalarial Activity of Quassinoids Against Chloroquine-Resistant Plasmodium Falciparum in VitroThe American Journal of Tropical Medicine and Hygiene, 1981
- Structural requirements of quassinoids for the inhibition of cell transformationBiochemical and Biophysical Research Communications, 1980
- Structural requirements for biological activity among antileukemic glaucarubolone ester quassinoidsJournal of Medicinal Chemistry, 1976