Carboxamide–pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals
- 25 January 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 13,p. 1369-1371
- https://doi.org/10.1039/b515510j
Abstract
The novel carboxamide–pyridine N-oxide synthon, sustained via N–H⋯O− hydrogen bonding and C–H⋯O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4′-bipyridine N,N′-dioxide.Keywords
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