Elucidation of structure of novel macrolide antibiotics produced by mutant strains of Streptomyces fradiae.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (4) , 376-382
- https://doi.org/10.7164/antibiotics.36.376
Abstract
The physicochemical characterization and proof of structure are reported for several new macrolide antibiotics related to tylosin which were obtained by fermentation of mutant strains of S. fradiae.This publication has 4 references indexed in Scilit:
- Biosynthesis of tylosin: Oxidations of 5-O-mycaminosylprtylonolide at C-20 and C-23 with a cell-free extract from StreptomycesfradiaeBiochemical and Biophysical Research Communications, 1982
- Chemical transformation of tylosin,a 16-membered macrolide,and its structure-activity relationship.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982
- Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylationsAntimicrobial Agents and Chemotherapy, 1981
- Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic TylosinAntimicrobial Agents and Chemotherapy, 1981