BLADDER STONE DISEASE OF CHILDHOOD II. A Clinico‐Pathological Study1

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Abstract
Summary: A clinico‐pathological study of 61 cases of bladder stone in children was undertaken. The patients showed some evidence of growth failure. In none of the patients renal or ureteral stone could be visualized.The serum calcium and plasma phosphorus levels were within normal limits. A significant finding in these cases was raised serum muco‐protein levels. The urinary mucoprotein levels in patients were one and a half to two times higher than in control children. Hypoalbuminemia was observed in 36.6% of the cases.Morphological studies of bladder biopsies revealed dark granular cells rich in PAS positive material.From the observations made, it has been suggested that the bladder stone disease of childhood is an entity distinct from renal lithiasis. The possible factors in the etiopathogenesis of the disease have been discussed.