Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
- 15 December 2003
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 19 (5) , 544-548
- https://doi.org/10.1002/mds.10695
Abstract
The parkin protein functions as a RING‐type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin‐proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age‐matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations. © 2003 Movement Disorder SocietyKeywords
Funding Information
- Scientific and Technical Research Council of Turkey (SBAG-2596, TBAG-1754)
- Hacettepe University Scientific Research Unit (0002101001)
This publication has 29 references indexed in Scilit:
- Effect of Wild-type or Mutant Parkin on Oxidative Damage, Nitric Oxide, Antioxidant Defenses, and the ProteasomeJournal of Biological Chemistry, 2002
- Parkinson's disease: one biochemical pathway to fit all genes?Trends in Molecular Medicine, 2002
- α-Synuclein Protects against Oxidative Stress via Inactivation of the c-Jun N-terminal Kinase Stress-signaling Pathway in Neuronal CellsJournal of Biological Chemistry, 2002
- Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease?Journal of Neurochemistry, 2002
- The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disordersTrends in Neurosciences, 2001
- Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?Mechanisms of Ageing and Development, 2001
- Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide productionJournal of Neurochemistry, 2001
- Glutathione Depletion in PC12 Results in Selective Inhibition of Mitochondrial Complex I ActivityJournal of Biological Chemistry, 2000
- Inhibitor sensitivity of respiratory complex I in human platelets: A possible biomarker of ageingFEBS Letters, 1996
- L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondriaMovement Disorders, 1991