Histoplasmosis

Abstract
THE acquisition of knowledge concerning the clinical features of histoplasmosis has followed that of many other newly recognized diseases. In 1906 Darling1 described a rapidly fatal disease involving primarily the reticuloendothelial system. Except for occasional reports, the next step was the recognition, in 1940,2 that asymptomatic pulmonary calcifications could result from infection by Histoplasma capsulatum. Since that time the gaps between the two extremes are being filled in. Outbreaks of mild atypical pneumonia, ulcers of the mucous membranes, pulmonary cavitation, chronic disseminated pulmonary disease and a variety of other lesions have been recognized. The purpose of this report is threefold: . . .

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