Synthesis and antiallergic activity of 2-hydroxy-3-nitro-1,4-naphthoquinones
- 1 August 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (8) , 1059-1064
- https://doi.org/10.1021/jm00218a014
Abstract
A selection of novel 2-hydroxy-3-nitro-1,4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The 2 most potent compounds produced a 50% inhibition in the rat PCA test at doses of about 10 .mu.M/kg following s.c. administration and showed activity after oral administration. Related 4-hydroxy-3-nitro-2(1H)-naphthalenones had no effect on rat PCA in doses up to 500 .mu.M/kg.This publication has 1 reference indexed in Scilit:
- 2-Cyano-1,3-dicarbonyl compounds with antiallergic activityJournal of Medicinal Chemistry, 1977