Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic Protozoan Leishmania donovani
- 23 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4557) , 369-371
- https://doi.org/10.1126/science.6124040
Abstract
Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani . These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.This publication has 9 references indexed in Scilit:
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