A Study of the Mechanism of the Schultz-Dale Reaction.

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Abstract
Summary A study has been made of the effects of a number of substances upon the Schultz-Dale reaction. For the most part, results in the literature concerning the effects of these substances were confirmed. The Schultz-Dale reaction, but not the responses due to histamine and acetylcholine, was blocked by urethane, Nupercaine, lower aliphatic alcohols, and type D botulinum toxin. The results are interpreted to indicate that the Schultz-Dale reaction involves postgan-glionic cholinergic nerve.