Host-controlled Changes of Staphylococcal Phage 3C Affecting its Broad Group Typing Pattern

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Abstract
Propagated on group II host, phage 3C behaves as a typical group II phage; but after passage on hosts of wide group patterns, Staphylococcus aureus K1. and 73, 3C phage is host-restricted, losing its potential for infecting group II hosts and gaining an increased potential for infecting group III hosts. Such a phage would be considered a group HI phage. The change occurs in the first burst of every infected cell. The phage released remains of A serology. Phage 3C can be propagated directly on several group HI cocci and in these hosts a similar host-restriction occurs. These observations constitute evidence that host-induced modifications can alter the group lytic spectrum of a specific typing phage.