Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Top Cited Papers
- 1 April 2004
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 22 (1) , 745-763
- https://doi.org/10.1146/annurev.immunol.22.012703.104702
Abstract
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCMand TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.Keywords
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