ACTIVE ENHANCEMENT OF CANINE LIVER ALLOGRAFTS - EFFECT OF PRETREATMENT WITH PREDNISOLONE AND DONOR-SPECIFIC ANTIGEN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 80  (5) , 565-568
Abstract
The active enhancement of liver allografts was investigated in 44 pairs of beagle dogs pretreated with semisoluble and soluble donor-specific spleen antigens. If the antigen were administered together with prednisolone, time of survival was significantly prolonged; with soluble antigen the graft was prolonged by 36.8 .+-. 5.9 days, and with semisoluble antigen it was prolonged by more than 3 yr. Antigen pretreatment alone or antigen in combination with postoperative treatment of minimal immunosuppressive drugs had no significant effects. There was no correlation between the titer of lymphocytotoxic antibodies in the serum of recipients at the time of transplantation and survival times.

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