The sxa2‐dependent inactivation of the P‐factor mating pheromone in the fission yeast Schizosaccharomyces pombe
- 1 April 1996
- journal article
- Published by Wiley in Molecular Microbiology
- Vol. 20 (1) , 35-42
- https://doi.org/10.1111/j.1365-2958.1996.tb02486.x
Abstract
Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P. Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue.Keywords
This publication has 38 references indexed in Scilit:
- The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.Genes & Development, 1994
- Signal Transduction During Pheromone Response in YeastAnnual Review of Cell Biology, 1991
- Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromoneCell, 1991
- The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domainCell, 1988
- The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromoneCell, 1988
- Down regulation of the α-factor pheromone receptor in S. cerevisiaeCell, 1986
- Initiation of meiotic recombination by double-strand DNA breaks in S. pombeCell, 1986
- Role of a ras homolog in the life cycle of schizosaccharomyces pombeCell, 1986
- POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine PeptidesAnnual Review of Biochemistry, 1984
- Control of yeast cell type by the mating type locusJournal of Molecular Biology, 1981