Renal Clearance of Fluoride in a Steady State Condition in Man: Influence of Urinary Flow and pH Changes by Diet

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Abstract
To study fluoride renal clearance, 4 subjects were given 3 mg fluoride as sodium fluoride tablets every 6 h for 60 h during 2 separate periods (during production of acid urine induced by a protein-rich diet and during production of alkaline urine obtained by giving a vegetarian diet). Plasma and urine were collected every 3rd h for 72 h during each experiment. In the protein-rich diet, period urinary pH was significantly lower than when the subjects were maintained on the vegetarian diet. Lower urinary output of fluoride during the protein-rich diet experiment was recorded and the difference was not significant. Plasma fluoride at steady state was almost the same during both experiments. Renal fluoride clearance was significantly correlated to urinary pH in both types of experiments. When renal fluoride clearance was plotted vs. urinary flow, the correlation was only significant during alkaline conditions. The average renal clearance was not significantly different between the 2 sets of experiments. pH and diuresis both influence fluoride renal clearance. Dietary components as such may influence renal clearance of fluoride.

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