Correlations Between the Distribution Coefficients and the Capacity Factors in Reverse HPLC of N-Pyrrolyl Derivative Acids

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Abstract
The distribution coefficients in octanol-water of the dissociated and non-dissociated forms for eleven N-pyrrolyl derivative acids which possess analgesic properties and plaquetary antiaggregating agents are determined. Likewise the capacity factors have been determined by reverse HPLC, and a study has been made of relationship between the two types of coefficients.