Dispersal of NK homeobox gene clusters in amphioxus and humans
- 18 April 2003
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 100 (9) , 5292-5295
- https://doi.org/10.1073/pnas.0836141100
Abstract
The Drosophila melanogaster genome has six physically clustered NK-related homeobox genes in just 180 kb. Here we show that the NK homeobox gene cluster was an ancient feature of bilaterian animal genomes, but has been secondarily split in chordate ancestry. The NK homeobox gene clusters of amphioxus and vertebrates are each split and dispersed at two equivalent intergenic positions. From the ancestral NK gene cluster, only the Tlx-Lbx and NK3-NK4 linkages have been retained in chordates. This evolutionary pattern is in marked contrast to the Hox and ParaHox gene clusters, which are compact in amphioxus and vertebrates, but have been disrupted in Drosophila.Keywords
This publication has 25 references indexed in Scilit:
- Fluorescentin situHybridisation to Amphioxus ChromosomesZoological Science, 2002
- The Genome Sequence of the Malaria Mosquito Anopheles gambiaeScience, 2002
- Fourfold Faster Rate of Genome Rearrangement in Nematodes Than in DrosophilaGenome Research, 2002
- Were vertebrates octoploid?Philosophical Transactions Of The Royal Society B-Biological Sciences, 2002
- Sipunculan ParaHox genesEvolution & Development, 2001
- Characterization of amphioxus amphivent, an evolutionarily conserved marker for chordate ventral mesodermGenesis, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- Splits in fruitfly Hox gene complexesNature, 1996
- A possible Early Cambrian chordateNature, 1995
- Archetypal organization of the amphioxus Hox gene clusterNature, 1994