The metabolism of 1,3-dibromopropane by the rat
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 11 (8) , 541-546
- https://doi.org/10.3109/00498258109045865
Abstract
The metabolism of 1,3-dibromopropane was investigated in the rat. Two conjugated metabolites were isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine. An oxidation product, identified as .beta.-bromolactic acid, was isolated as a urinary metabolite. 1,3-Dibromopropane was not excreted unchanged in expired air or in the urine; .apprx. 15% of the dose (100 mg/kg) was excreted as metabolic products over 50 h and 3.5% as CO2 within 6 h, indicating that oxidation was the main route of detoxication.This publication has 18 references indexed in Scilit:
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