Antibiotic Prophylaxis in Open and Closed Fractures:A Controlled Clinical Trial

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Abstract
The value of prophylactic antibiotics in fracture surgery was studied in a series of 90 patients with open fractures of various bones and 180 patients with closed malleolar fractures treated by open surgery. Dicloxacillin and benzyl were compared to saline (placebo). The soft tissue lesions of the open fractures were divided into grade I wounds and grade II and III wounds. Of the patients with grade I wounds, 17 received dicloxacillin, 21 benzyl penicillin and 17 saline. No major infections occurred. Patients (12) with grade II and III wounds were treated with dicloxacillin, 10 with benzyl penicillin and 13 with saline. In the saline group, 2 patients developed a deep infection. Patients (58) with closed malleolar fractures received dicloxacillin, 59 benzyl penicillin and 63 saline. Two infections developed in the placebo group. A statistically significant difference was found between the number of infections in the antibiotic groups and the number in the placebo group. Superficial thrombophlebitis following the antibiotic infusion occurred in 16% of the dicloxacillin treated patients and in 1% of those treated with benzyl penicillin or placebo.

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