UGA suppression by normal tRNATrPin Escherichia coli: codon context effects
Open Access
- 25 February 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 9 (4) , 983-991
- https://doi.org/10.1093/nar/9.4.983
Abstract
The nucleotide sequences at the 3′ side of in-phase UGA termination codons in mRNAs of various prokaryotic genes were re-examined. An adenine (A) residue is found to be adjacent to the 3′ side of UGA in mRNAs which code for readthrough proteins by the suppression of UGA by normal Escherichia coli tRNATrp. It is suggested that the nature of the nucleotide following a UGA codon determines whether the UGA signals inefficiently or efficiently the termination of polypeptide chain synthesis: an A residue at this position permits the UGA readthrough process.Keywords
This publication has 42 references indexed in Scilit:
- Codon—anticodon pairing: The wobble hypothesisPublished by Elsevier ,2009
- DNA sequence of the int-xis-P1region of the bacteriophage lambda; overlap of the int and xis genesNucleic Acids Research, 1980
- Structure and Function of Phage RNAAnnual Review of Biochemistry, 1973
- Free energy of imperfect nucleic acid helices: II. Small Hairpin LoopsJournal of Molecular Biology, 1973
- Possible Origin of a Minor Virus Specific Protein (A1) in Qβ ParticlesNature New Biology, 1971
- Gene products of bacteriophage QβVirology, 1971
- Translation of the UGA triplet in vitro by tryptophan transfer RNA'sJournal of Molecular Biology, 1971
- Tryptophan transfer RNA as the UGA suppressorJournal of Molecular Biology, 1971
- Adjacent effect on suppression efficiencyMolecular Genetics and Genomics, 1970
- The influence of the reading context upon the suppression of nonsense codonsMolecular Genetics and Genomics, 1969