Studies on Carbohydrate Metabolism in Hypercholesteremic Rhesus Monkeys.

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Abstract
Hypercholesteremia produced in rhesus monkeys by feeding cholesterol and vegetable oils, was associated with defective utilization of glucose as evidenced by diminished glucose tolerance and increased plasma [non-esterified fatty acids] (NEFA) values. Hypercholesteremic rhesus monkeys excreted increased amounts of 17-ketosteroids and had diminished plasma insulin-like activity. The impaired carbohydrate metabolism of these animals was possibly due to combined effects of insulin insufficiency and hyperfunction of the adrenal cortex.