Effect of Vitamin E-Deficiency on Protein Synthesis in Skeletal Muscle of the Rabbit.
- 1 January 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (1) , 8-10
- https://doi.org/10.3181/00379727-109-27085
Abstract
Normal and vitamin E-deficient rabbits were injected with glycine-1-C14 and sacrificed at time intervals ranging from 0.5 to 12 hours. Homogenates of skeletal muscle were fractionated by differential centrifugation, and the specific activity of the subcellular protein fractions determined. In all subcellular fractions and at all time intervals the proteins of vitamin E deficient animals had a much higher specific activity. The effect of vitamin E deficiency on incorporation of glycine-C14 was approximately the same in all subcellular protein fractions. Compared with control animals the radioactivity of the non-protein supernatant fraction rose and fell faster in muscle of vitamin E-deficient animals.Keywords
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