The Combined Effect of Quipazine and Haloperidol on Plasma Prolactin Release

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Abstract
The possible dopaminergic properties of the central serotonergic agonist quipazine was examined using plasma prolactin release in rats as a model to determine whether quipazine exerts an agonist effect on only serotonin [5HT] receptors or on dopamine [DA] receptors as well. Drugs acting on 2 different receptors have only an additive effect on the same parameter while different drugs acting on the same receptor exert a synergistic effect. It was determined whether combining quipazine with haloperidol, which has no effect on serotonin receptors, would produce a synergistic or only an additive effect on prolactin release, relative to the release induced by quipazine alone. A distinct synergism was produced, suggesting that quipazine acts on both DA and 5-HT receptors. The model used may be useful for distinguishing whether a given drug acts on 1 or 2 receptors concurrently.