Abstract
Both pancreatic ducts were ligated in 3 dogs. Over a period of 24 hrs. a gradual rise of serum amylase occurred and a moderate edema of the pancreas with a slight leukocytic infiltration of the interlobular connective tissue. The pancreatic duct systems of 5 dogs were subjected to a pressure of 30 cm. water. Serum amylase rose twice as fast as in the dogs with simple ligation and the leukocytic infiltration, including acinar areas, and degeneration of some acinar cells was more intense.

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