EFFECTS OF LIGATION OF THE PANCREATIC DUCT UPON THE ACTION OF SECRETIN AND PANCREOZYMIN IN RABBITS WITH A CORRELATED HISTOLOGICAL STUDY

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Abstract
The effect of ligation of the pancreatic duct on the action of secretin and pancreozymin in rabbits has been observed and a correlated histological study of the pancreas has been performed. Ligation of the pancreatic duct brought about a marked change in the pancreas both histologically and functionally. The rate of decline in functional performance was very rapid in the first 4 days of ligation and then fell gradually so that by the end of 2 weeks no pancreatic secretory activity was present. The loss of function after different durations of ligation was correlated closely with the picture of degeneration of the cells as revealed histologically. The observations indicate that the effect of pancreozymin tends to disappear in the degenerating pancreas before the disappearance of secretin action.