Effects of γ-Globulin Therapy in Severely Epileptic Children

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Abstract
The effects of .gamma.-globulin therapy [previously used in the treatment of allergic seasonal diseases] were studied from clinical, immunological and electrographic perspectives in 10 children affected by severe organic epilepsy. After the 1st or the 2nd injection of large doses of IgG, an appreciable reduction in seizure frequency and an improvement in behavioral and psychological performance were observed in 7 children. These clinical modifications were not correlated with an important decrease of the EEG epileptic elements, but in most cases they were associated to an increase in .alpha. activity and/or in power of the predominant EEG frequency. These changes were observed during the entire treatment period and tended to disappear when therapy was interrupted. No significant changes in both immunological data and plasma levels of antiepileptic drugs accompanied the clinical and EEG changes.