Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
- 1 December 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 336 (6201) , 738-744
- https://doi.org/10.1038/336738a0
Abstract
Cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.Keywords
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